| |
Alfonso
GONZALEZ
MD, Ph.D. Associate Professor, Faculty
of Medicine, Pontificia Universidad Católica de Chile;
Presidential Chair in Science.
Dr
González has made important
contributions to the knowledge of epidermal growth factor
function in differentiated cells making one of the earliest
reports implicating the cytoskeleton in the cellular actions
of a growth factor. At present his research is centered on the mechanisms by
which epithelial cells segregate selected proteins to specific
domains of their cell surface, a pivotal process in the determination
of their polarized apical-basolateral phenotype. In addition,
due to his medical background and commitment with the School
of Medicine, he carries out research on the molecular background
underlying autoimmunity. He has found that usual markers of
susceptibility and/or disease severity of rheumatoid arthritis
have limited importance in the Chilean population, and gave
evidence of a novel marker of this disease. More recently,
he has found evidence that T lymphocytes from lupus patients
exhibit anomalies in the expression of c-Rel, a transcription
factor of the NFkB/Rel family encoded by the proto-oncogene
c-rel which is involved in the control of immuneresponsive
genes. Dr. González has been a consultant for the Chilean
Ministry of Education and Coordinator of the Biology Program
for High School students
ACADEMIC
POSITIONS: Associate
Professor. Head of the Immunopathology Unit of the Department
of Clinical Immunology and Rheumatology, School of Medicine.
Pontificia Universidad Católica de
Chile. Joint
appointment as Associate Professor at the Department of Cellular
and Molecular Biology, Faculty of Biological Sciences,. Pontificia Universidad Católica de
Chile.
SELECTED PUBLICATIONS
Gonzalez, A., Rizzolo, L.J., Rindler, M.J., Adesnik,
M.B., Sabatini, D.D. and Gottlieb, T.A. (1987). Nonpolarized
secretion of trucanted forms of the influenza virus hemaglutin
and the g protein from mdck cells. Proc. Natl. Acad.Sci. Usa 84, 3738-3742.
Faúndez,
V., Krauss, R., Holuigue, L., Garrido, J., Gonzalez A. (1992). Epidermal growth factor receptor in synaptic
fractions of the rat central nervous system. J. Biol. Chem.
267, 20363-370.
Gonzalez, A., Nicovani, S., Juica, F., Bull, P.
(1993). Apical
secretion of the hepatitis B surface antigen from a polarized
epithelial cell. J. Biol. Chem. 268, 6662-6667.
Marzolo,
M.P., Bull, P. Gonzalez, A. (1997). Apical sorting of hepatitis B surface antigen (HBsAg) is independent
of n-glycosylation and glycosylphosphatidylinositol-anchored
protein segregation. Proc. Natl. Acad. Sci. Usa. 94, 1834-1839.
Rodriguez-Boulan,
E. and GonzAlez,
A. (1999). Glycans
in apical targeting: sorting signals or structural props?
Trens Cell Biol 9, 291-294.
Mardonez, G. and GONZÁLEZ, A. “Selective plasma membrane permeabilization by freeze-thawing
and immunofluorescence epitope access to determine the topology
of intracellular membrane proteins”. J. Immunol. Methods 9294:
1-9.
Massardo,
L., Burgos, P., Martínez, M.E., Pérez, R., Calvo, M., Barros,
J., GONZÁLEZ, A. and Jacobelli, S. (2002).
“Antiribosomal P protein antibodies in Chilean
SLE patients: no association with renal disease”. Lupus
11: 379-83.
Salazar,
G. and GONZÁLEZ, A.
(2002). “Novel mechanism for regulation of epidermal
growth factor receptor endocytosis revealed by protein kinase
A Inhibition”. Mol. Biol. 13: 1677-1693. |
|
