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Enrique
Brandan Ph.D. Professor,
Pontificia Universidad Católica
de Chile; Howard Hughes International Fellow; Presidential
Chair in Science.
Professor
Enrique Brandan is a well known Chilean cell and molecular
biologist. His doctoral work was one of earliest demonstration
and a classic example of enzyme-proteoglycan interaction.
In 1986 he joined the laboratory of Dr. Carlos B. Hirschberg,
Department of Biochemistry, St. Louis University, and in1987
he was appointed Assistant Professor at the Department of
Biochemistry, University of Massachusetts Medical Center,
where he studied how heparan sulfate proteoglycans are associated
with organelle membranes. In November 1998 he was appointed
Full Professor at the Pontificia Universidad Católica de Chile
where he started his research toward the understanding of
the function of skeletal muscle proteoglycans. Presently his
research is related to understanding how components
of the extracellular matrix regulates skeletal muscle cell
differentiation. Dr. Brandan is a Howard Hughes Fellow and
was awarded the Chilean Presidential Chair in Sciences.
ACADEMIC POSITIONS:
Several appointments in national and international institutions.
Undergraduate, Graduate and Post-Graduate teaching responsibilities
in Cell and Molecular Biology. Professor, Faculty of Biological
Sciences (www.bio.puc.cl),
Department of Cell and Molecular Biology, Pontificia Universidad
Católica de Chile
PUBLICATIONS:
55
original articles with a total of 371 citations, 4 chapter
in books.
SELECTED PUBLICATIONS
Larraín, J., Cizmeci-Smith, G., Troncoso,
V., Stahl, R.C., Carey, D.J. and
BRANDAN, E. (1997). Syndecan-1 expression is downregulated
during myoblasts terminal differentiation: Modulation by growth
factors and retinoic acid. J. Biol. Chem. 272, 18418-18424.
Larraín, J, Carey, D and BRANDAN, E. (1998). Mantainence of syndecan-1
expression blocks myoblast differentiation interfering with
the myogenic regulator myogenin through a basic fibroblast
growth factor dependent mechanism. J. Biol. Chem. 273, 32288-32296.
Alvarez, K., Fadic, R. and Brandan,
E. (2002). “Augmented synthesis and differential localization
of heparan sulfate proteoglycans in Duchenne muscular dystrophy”.
J. Cell. Biochem. 85: 703-713.
Henríquez, J.P., Casar, J.C., Fuentealba,
L, Carey, D.J. and BRANDAN,
E. (2002). “Extracellular matriz histone H1 binds to perlecan,
is present in regenerating skeletal muscle and stimulates
myoblast proliferation”. J. Cell. Sci. 115: 2041-2051.
López-Casillas, F., Riquelme, C., Pérez,
Kato, Y., Ponce-Castañeda, M.V., Osses, N., Esparza-López,
J., González-Núñez, G., Cabello-Verrugio, C., Mendoza, V.,
Troncoso, V., BRANDAN, E. “Betaglycan expression is transcriptionally up-regulated
during skeletal muscle differentiation”. J. Biol. Chem. 278:
382-390.
Osses, N. and BRANDAN, E. (2002). “ECM is required for skeletal muscle differentiation
independently of muscle regulatory factor expression”. Amer.
J. Physiol. Cell Physiol 282: C383-C394.
INESTROSA, N.C., Aldunate, R., Casar, J.C.
and BRANDAN, E.
“Structural and functional organization of synaptic acetylcholinesterase”.
Brain Res. Rev. (In press).
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