| |
María
Paz MARZOLO Ph.D. Associate Scientist, FONDAP in Biomedicine.
Assistant Professor, Pontificia
Universidad Católica de Chile.
Dr. Marzolo´s prior research is related
to hepatic lipoprotein metabolism and cholesterol transport
and their link to cholesterol gallstone disease and atherosclerosis.
She did her undergraduate thesis in the Gastroenterology
Department in the Pontificia Universidad
Católica de Chile and acquired expertise in evaluating
hepatic cholesterol-related metabolic and physiologic parameters
in rodents. As graduate student Dr. Marzolo worked on the
molecular and cellular determinants of the cell polarity and
sorting. Her work was published in PNAS 1997. Dr. Marzolo
worked as a postdoctoral fellow in the Neurobiology Lab.,
in the Cellular and Molecular Biology Department at the Pontificia
Universidad Católica de Chile, where she studied the expression
and function of LRP and mannose receptor in microglia and
astrocytes. In 1999 Dr. Marzolo got an academic position in
Faculty of Sciences, Universidad
de Chile, where she started her independent career
obtaining her first Fondecyt grant for a period of three years.
Her current work is related to the cell biology of intracellular
protein trafficking, sorting and polarity. More recently,
Dr. Marzolo has been involved in several graduate and undergraduate
courses and thesis committees.
RESEARCH: Dr. Marzolo’s laboratory is interested in understanding the cell biology
of intracellular protein trafficking, especially in polarized
epithelial cells and neurons. Their studies are focused primarily
on the large endocytic receptors, the low-density lipoprotein
receptor-related protein (LRP), megalin and ApoER2, which
belong to the low-density lipoprotein receptor (LDL-R) family.
Their aim is to identify molecular elements within the cytoplasmic
tail of the LDLR-related receptors and cellular components
that govern their trafficking and signaling in polarized cells.
Another aspect of Dr. Marzolo’s research the endocytic trafficking
of receptors, work that is being carried out in collaboration
with Dr. Guojun Bu.
ACADEMIC
POSITIONS: Undergraduate, Graduate and teaching responsibilities in Cell and Molecular
Biology. Assistant Professor, Faculty
of Biological Sciences, Department of Cell and
Molecular Biology, Pontificia Universidad Católica de Chile
PUBLICATIONS: 16 publications in mainstream journals and 1 book chapter.
SELECTED PUBLICATIONS
Marzolo,
M.P., Bull, P. and Gonzalez, A. (1997). “Apical Sorting of hepatitis B surface
antigen (HBsAg) is independent on N-Glycosylation and GPI-anchored
protein segregation”. Proc. Natl. Acad. Sci., 94: 1834-1839.
Marzolo,
M.P., von Bernhardi, R., Bu, G. and Inestrosa,
N.I. (2000). Expression of _2-macroglobulin receptor/low density
lipoprotein receptor related protein (LRP) in rat microglial
cells. J. Neurosci. Res.1;60(3):401-411
Li
Y, Marzolo MP, Kerkhof Pv, Strous GJ, Bu .(2000). The
YXXL motif, but not the two NPXY motifs, serves as the dominant
endocytosis signal for LDL receptor-related Protein (LRP)
. J.Biol.Chem 275(22):17187-17194.
Bu,
G. and Marzolo M.P (2000) Role of RAP in the biogenesis
of lipoprotein receptors. Trends in Cardiovascular Medicine,
10: 148-155
Li,
Y., van Kerkhof, P., Marzolo, MP, Strous, G.J. and
Bu, G. (2001). Identification of a major PKA phosphorylation
site within the cytoplasmic tail of LRP: Implication for receptor-mediated
endocytosis., Mol Cell Biol., 21(4): 1185-1195.
Li,
Y., Lu, W, Marzolo MP. and Bu, G. (2001). Differential
functions of members of the LDL receptor family suggested
by their distinct endocytosis rates. J Biol Chem. 276(21):18000-18006.
Marzolo
MP, Yuseff MI, Retamal C, Donoso M, Ezquer
F, Farfán P, Li Y and Bu G (2003). Differential Distribution
of LRP and Megalin, in Polarized Epithelial Cells is Determined
by their Cytoplasmic Domains. Traffic, 4: 273-288.
|
|
