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Dr. Bono, a renowned Chilean
immunologist begun undergraduate studies in Chemistry at the
Faculty of Science, University of Chile. In 1974 she traveled
to France where she obtained a "Maîtrisse in Physical
Chemistry" at the Faculty of Sciences, University of
Paris. Pursuing
her studies she became increasingly interested in Biology
and in 1978, she gained a post-doctoral fellowship intended
to support graduate students wishing to "convert"
to Biology. This fellowship gave her the opportunity to work
in the laboratory of Nobel Laureate Jean Dausset, obtaining
a "Diplôme in Immunology" at the Pasteur Institute.
Since then she has continue to work in histocompatibility
molecules. As a postdoctoral Fellow at Dr. Jack Strominger
's lab at Harvard University, she discobered that human HLA-DR
molecules were the equivalent of the mouse I-E and that DC-1
and that HLA-DQ was the equivalent of I-A antigens. In 1983,
she returned to France were she obtained a permanent position
at the CNRS. Back in France she started research on the mechanism
by which IFN-g regulates MHC Class II expression. In 1991
she took a position at the Faculty of Sciences of the University
of Chile where she created the Immunology Laboratory and started
a vigorous research on immunology. Dr. Bono is the recipient
of several international prices.
ACADEMIC
POSITIONS:
Associate Professor, Faculty of Sciences University of Chile,
Invited Professor. Institute Adolfo Lutz, Sao Paulo, Brazil,
Invited Profesor. Faculty of Sciences, University of Paris.
PUBLICATIONS: 52 publications in mainstream journals
and two book chapters.
SELECTED
PUBLICATIONS
BONO,
M.R.,
Reyes, L.I. and M. ROSEMBLATT. "A flow cytometric
procedure for the quantification of cell adhesion in complex
mixtues of cells". J. Immunol. Meth. 223: 27-36
(1999).
C. Hetz, M.R. BONO, L.F. Barros and
R. Lagos. “Microcin E492, a channel forming bacteriocin from
Klebsiella pneumoniae, induces apoptosis in some human cell
lines”. PNAS 99: 2696-2701 (2002).
R. Naves, A.M. Lennon, G. Barbieri, L. Reyes,
G. Puga, L. Salas, V. Deffresnnes, M. ROSEMBLATT, M.
Fellous, D. Charron, C. Alacide-Loridan and M.R. BONO.
“MHC class-II deficient tumor cell lines with a defective
expression of the class-II transactivator (CIITA)”. Int. Immunol.,
14: 481-591 (2002).
L. I. Reyes, P. Escobar, M. R. BONO
and M. ROSEMBLATT. B Lymphocyte “Adhesion to Endothelial
Cells from Human Lymphoid Tissue Modulates Tyrosine Phosphorylation
and Endothelial Cell Activation”. J. Immunol. 169: 5881-5888
(2002)
D. Sauma, J.R. Mora, A. Fierro, J. Morales,
C. Herzog, E. Buckel, M. ROSEMBLATT and M.R. BONO.
“Low-dose prednisone accounts for the marked reduction on
CD4+ and CD8+ T cells in renal transplant patients under triple
therapy”. Transplantation Proceedings 34: 3183-3184 (2002).
A. Fierro, J.R. Mora, M.R. BONO,
J. Morales, E. Buckel, D. Sauma and M. ROSEMBLATT.
“Dendritic cells and the mode of action of anticalcineurinic
drugs. An integrating hypothesis” Nephrology Dialysis Transplantation.
18: 467-468 (2003).
J.R. Mora, M.R. BONO, N. Manjunath, W. Weninger, L.L. Cavanagh, M.
ROSEMBLATT and U. H. von Andrian. “Selective imprinting
of gut-homing T cells by Peyer’s patch dendritic cells”. In
press, Nature (2003).
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