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Miguel Bronfman Ph.D. Professor and Chairman,
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad
Católica de Chile; Presidential Chair in Science (1998).
Dr. Bronfman did his doctoral
training at the laboratory of Biochemical Cytology of Prof.
C. de Duve, in Belgium. InBelgium he was awarded the "Pierre
Bruylands Award" by the Chemist Association of Louvain
for his outstanding work during his doctoral work. After a period of post-doctoral training
at the Department of Biochemistry at the University of Wisconsin-Madison
he described for the first time the existence of the peroxisomal
fatty acid oxidizing system in human liver.
He is Full Professor at the Catholic University of Chile where he has directed
several doctoral students. His present research
intrests are centered in understanding the role
of PPARs (Peroxisome proliferator activated receptors) in
the regulation of cell differentiation and lipid homeostasis.
These ligand-activated receptors have been shown to be involved
in a number of diseases, such as obesity, diabetes and cancer.
They are the target of peroxisome proliferators, a class on
non-genotoxic carcinogens including hypolipidemic drugs, plastizisers,
pesticides and other environmental contaminants, and of the
thiazolendiones antidiabetic drugs. Besides the Pierre Bruylands
Award Dr. Bronfman received the Edmond Rothschild Foundation
Fellowship, the Medical Association of Santiago Award, the
Fundación Andes Award and the Presidential Chair in Sciences
from the Chilean Governement.
SELECTED
PUBLICATIONS
Bronfman,
M., Orellana, A., Morales, M.N., Bieri, F.,
Waetcher, F., Staubli, W., and Bentley, P. (1989). Potentiation
of diacylglycerol-activated protein kinase C by acyl-Coenzyme
A thioesters of hypolipidaemic drugs. Biochem. Biophys. Res.
Commun. 159,1026-1031.
Bronfman,
M., Morales, M.N. and Orellana, A. (1988).
Diacylglycerol activation of protein kinase C is modulated
by long-chain acyl-CoA. Biochem. Biophys. Res. Commun. 152,
987-993.
Bronfman,
M., Amigo, L., and Morales, M.N. (1986). Activation
of hypolipidemic drugs to acyl-coenzyme A thioesters. Biochem.
J. 239, 781-784.
Bronfman,
M., INESTROSA, N.C., Nervi, F.O., and
Leighton, F. (1984). Acyl-CoA Synthetase and the peroxisomal
enzymes of oxidation in human liver. Quantitative analysis
of their subcellular localization. Biochem. J. 224, 709-720.
Bronfman,
M., INESTROSA, N., and Leighton, F.
(1979). Fatty acid oxidation by human liver peroxisomes. Biochem.
Biophys. Res. Commun. 88, 1030.
Coddou,
C., Loyola, G., Boyer, J.L., BRONFMAN, M. and
HUIDOBRO-TORO,
J.P. “The hypolipidemic drug metabolites nafenopin-CoA and ciprofibroyl-CoA
are competitive P2Y1 receptor antagonists”. FEBS
536: 145-150.
Garrido,
J.L., Godoy, J., Alvarez, A., BRONFMAN, M. and INESTROSA,
N.C. (2002). “Protein kinase C inhibits amyloid _-peptide neurotoxicity
by acting on members of the Wnt pathway”. FASEB
J. 16: 1982-1984.
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