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Vivian
WILHELM Ph.D. Associate Scientist, Fundación Ciencia para la Vida
and Millennium Institute for Fundamental and Applied Biology.
Dr. Wilhelm begun
her undergraduate studies in Biochemistry at the Faculty
of Biochemistry, University of Conception. In 1990 she joined
the laboratory of Dr. Jorge Allende, Department of Biochemistry,
University of Chile were she accomplished work towards her
doctoral thesis. Dr. Wilhelm’s area of research was the
genomic structure of the gene codifying for the protein
kinase CK2 and its expression during the oogenesis and embriogenesis
of Xenopus laevis. In 1996 she obtained her doctoral degree in Cell and
Molecular Biology of the Faculty of Science, University
of Chile.
RESEARCH: Dr. Vivian Wilhelm is currently collaborating with Dr.
Pablo Valenzuela in the development of genetic and recombinant
vaccines against the salmon pathogen P.
salmonis. This obligate intracellular bacterium
is the etiological agent of piscirickettsiosis, a devastating
disease of maricultured salmonids in Chile.The genome of this
gram negative bacteria has been recently sequenced at the
Fundación Ciencia para la Vida and around 1,500 genes has
been identified. Based on these sequences the group has isolated
and expressed 20 genes related with virulence or host-pathogen
interaction. The main goal is to test these
genes and their recombinant proteins as experimental
vaccines against P. salmonis in salmons.
ACADEMIC POSITIONS:
Junior Investigator at Fundación Ciencia para la Vida.
PUBLICATIONS: 4 publication in international journals and 1 book chapter
SELECTED PUBLICATIONS:
Imschenetzky, M., Wilhelm,
V., Puchi, M. and Medina,
R.(1995). “In sea urchin embryos the translation of cleavage
stage histone variants is confined to S phase and is partially
uncoupled from DNA replication.”
Biological Research 28: 131 – 140
Wilhelm, V., Rojas, P., Gatica, M., Allende, C.C. and Allende, J.E. (1995) “Expression of the subunits of protein kinase
CK2 during oogenesis in Xenopus
laevis.European Journal of Biochemestry 232: 671 – 676
Wilhelm, V., Neckelman, G.,
Allende, C.C. and Allende, J.E. (2001)
The Genomic Structure of Two Protein Kinase CK2 alpha
Genes of Xenopus laevis and Features of the Putative Promoter
Region. Molecular
and Cellular Biochemistry 227: 175-183
Wilhelm, V., Engel, E., Miquel,
A., Jamett, A., Aguayo, J., Müller, I.,
Hernández, C., Soza, C., Villegas, J., Bernales, S., Martínez,
R.,Rosemblatt, M., Burzio, L.O. and Valenzuela, P.D.T. (2003).
“Piscirickettsia
salmonis: Un
enfoque genómico para un problema de la salmonicultura”.
Biotecnología Marina, Paniagua, J. (ed).
México (In Press).
Wilhelm, V., Villegas, J.,
Miquel, A., Engel, E., Bernales, S., Valenzuela,
P.D.T. and Burzio, L.O. (2003).
The complete sequence of the mitochondrial genome of
the Chinook salmon, Oncorhynchus tshawytscha.
Gene
(Submitted).
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